Effect of rehabilitative exercise and spinal manipulative therapy on veteran with chronic diffuse spine pain: A case report

IntroductionPatient is a 57-year-old male veteran with complaints of musculoskeletal origin. The patient was treated with rehabilitative exercise, manual therapy, and spinal manipulative therapy. Treatment helped improve the patient's ability to perform ADLs and is reflected in rehabilitative exercise progression and objective findings.Case presentationThe patient is a 57-year-old male veteran who presented with chronic cervical, thoracic, and lumbar pain. Range of motion was decreased and painful during all active ranges of motion. Each region had degenerative changes at various levels confirmed via radiographs. Rehabilitative exercise was directed with results from a Selective Functional Movement Assessment (SFMA). Patient was treated with manual therapy and spinal manipulative therapy (SMT). Rehabilitative exercises were selected to improve the patient's ADLs based on goals, to target chief complaints, and correct SFMA findings.Management and outcomeThe patient's progress was tracked with progression in rehabilitative exercise. The patient's objective findings continually improved throughout the care plan. At the end of the care plan, the patient underwent the same examination, and the objective findings were compared. There was an improvement across all objective testing.DiscussionThis case demonstrates the classic veteran with chronic diffuse spine pain that interferes with performance in their normal activities of daily living. This case demonstrated that the combination of soft tissue therapy, SMT and rehabilitative exercise can show an improvement in objective findings and help the patient meet their goals.     

The role of immune correlates of protection on the pathway to licensure,policy decision and use of group B Streptococcus vaccines for maternal immunization: considerations from World Health Organization consultations

The development of a group B Streptococcus (GBS) vaccine for maternal immunization constitutes a global public health priority, to prevent GBS-associated early life invasive disease, stillbirth, premature birth, maternal sepsis, adverse neurodevelopmental consequences, and to reduce perinatal antibiotic use. Sample size requirements for the conduct of a randomized placebo-controlled trial to assess vaccine efficacy against the most relevant clinical endpoints, under conditions of appropriate ethical standards of care, constitute a significant obstacle on the pathway to vaccine availability. Alternatively, indirect evidence of protection based on immunologic data from vaccine and sero-epidemiological studies, complemented by data from opsonophagocytic in vitro assays and animal models, could be considered as pivotal data for licensure, with subsequent confirmation of effectiveness against disease outcomes in post-licensure evaluations. Based on discussions initiated by the World Health Organization we present key considerations about the potential role of correlates of protection towards an accelerated pathway for GBS vaccine licensure and wide scale use. Priority activities to support progress to regulatory and policy decision are outlined.     

Fertility awareness-based methods of family planning

Fertility awareness-based methods (FABMs) of family planning involve monitoring various signs and symptoms of fertility during the menstrual cycle to identify the “fertile window,” or the days of the cycle when unprotected intercourse is most likely to result in pregnancy. Signs and symptoms include menstrual cycle length, basal body temperature, urinary hormone measurements, and/or cervical fluid and may be used alone or in combination. Fertility signs reflect both physiological changes during the menstrual cycle and the life cycle of the ovum and sperm. Women learn to observe or measure and interpret these signs according to the instructions of their chosen FABM and avoid unprotected intercourse on fertile days. FABMs are appropriate for those who choose to use them, are able and willing to observe one or more fertility signs, and are in relationships that support the use of a coitus-related method such as a condom or abstaining from intercourse on fertile days.     

Summary of the special symposium ‘Towards Elimination of Rubella’

A special symposium titled ‘Towards Elimination of Rubella’ was held at the 23rd Annual Meeting of the Japanese Society for Vaccinology in Tokyo, Japan on November 30, 2019. Representatives from the Japanese national government, a local government, and a private company presented their efforts to control rubella, and the group discussed the challenges of eliminating rubella in Japan.